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Re: Naltrexone to augment AD's?

Posted by bleauberry on September 10, 2010, at 15:46:07

In reply to Naltrexone to augment AD's?, posted by rovers95 on September 10, 2010, at 14:36:16

Very good potential. Not just for depression itself, but a large array of things that cause the depression in the first place.

BUT...dosing is the key. Doses are a tiny 1.5mg to 4.5mg at bedtime. The lowest dose you can buy is 50mg. So it needs to be made by a compounding pharmacy. The fillers are important too, because you want immediate release. Some common fillers actually slow the absorption down, and that is not good.

The idea is to trick the receptors into thinking there aren't enough natural opioids briefly during sleep when production is at its highest. Opioid production speeds up. And from personal experience I can say with some confidence there is an indirect influence in boosting dopamine, as well as some unknown benefit in helping serotonin as well.

To learn more, type LDN into a google search box and find the LDN home page. You will find out everything there is to know there, including pharmacies that specialize in this.

Even by itself I found it to be a fairly good, anti-anhedonia, pro-social, anti-anxiety. Side effects are usually disturbed sleep and maybe some slight decrease in appetite for a few days. At such a tiny dose with so many potential benefits, I believe it should be standard protocol for everyone to try it.

It rarely turns out to be a miracle by itself. The vast majority of people who try it find it provides enough benefit in one way or another that they don't want to go without it. There are failures but they are not that common. People who use it for MS and other diseases commonly see their symptoms get worse for a few weeks before getting better....probably some bizarre immunopathology going on as the immune system first gets boosted and then second gets reset to normal.

Many years ago there was a fad here started by a doctor who was having success adding Naltrexone to SSRIs, primarily prozac, in doses of 25mg to 50mg. Some of us tried it and none of us got anything good from it. Now we know why. The dose was exceedingly too high...permanently blocking the opioid receptors. We only want to briefly block them at night for a few hours.




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