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Re: nortripytline + MAOi? anti histamine interraction

Posted by linkadge on September 10, 2010, at 10:28:34

In reply to Re: nortripytline + MAOi? anti histamine interraction SLS, posted by Conundrum on September 10, 2010, at 8:13:41

>Perhaps EMSAM with nortriptyline would be a >safer combo. one could add zoloft if some SRI >were needed.

>Damn that would be one sick combo. It would hit >dopamine hard especially in the prefrontal >cortex. NE would be boosted along with >serotonin, but probably not enough to become >blunted if the dose were low.

Meh, I've gone away from getting excited about the way a drug "should" feel on paper. Mice lacking both the NET transporter and MAO-B have greatly increased cardiac NE levels and blood pressure. Dopamine in the prefrontal cortex isn't the be all too. Some studies show that there is hypermetabolism in the prefrontal cortex in certain depressive states. In ketamine responders, for instance, there is a dramatic *decrease* in prefrontal metabolism. I think there are studies showing the same in SSRI responses.

Too much dopamine in the prefrontal cortex can make you irritable, obsessive, and unable to shut drives / thoughs off.

I combined nortriptyline with the herb Fo-ti (a herbal MAOI with relative selectivity towards MAO-B). It was the worst experience of my life. I totally flew off the handle.

Linkadge


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URL: http://www.dr-bob.org/babble/20100908/msgs/961921.html