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Re: nortripytline + MAOi? anti histamine interraction SLS

Posted by linkadge on September 10, 2010, at 10:21:56

In reply to Re: nortripytline + MAOi? anti histamine interraction Conundrum, posted by SLS on September 10, 2010, at 8:06:43

I don't really know of any evidence that nardil and parnate are substantially different in their MAO effect. Both drugs inhibit both MAOA/B roughly equally.

The difference may be due to secondary activities of the two agents. Nardil inhibits GABA metabolism leading to higher levels of GABA. This could counteract some of the stimulatory nature of the drug.

Perhaps nardil is more potent an MAOI i.e. more inhibition at lower doses?





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