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Re: nortripytline + MAOi? anti histamine interraction

Posted by linkadge on September 10, 2010, at 10:18:00

In reply to Re: nortripytline + MAOi? anti histamine interraction linkadge, posted by Conundrum on September 10, 2010, at 7:50:00

The problem occurs when your combine potent serotonin reuptake inhibition with MAO-A inhibition. As a result, the body cannot properly metabolize serotonin leading to excessive levels. This results in serotonin syndrome (a potentially life threateneing condition).

Since nortriptyline is much more potent a NRI, it has generally been used safely with MAOIs





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