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Seroquel and effect on depression?

Posted by sk85 on September 9, 2010, at 10:39:36

I was put on Seroquel (100 mg at nighttime) to treat depression and anxiety as I'm intolerant to SSRIs and SNRIs (they make me dystonic). The good news is that Seroquel doesn't seem to make my movement disorder worse (maybe even slightly better) and it's effects on anxiety are pretty good also (though, only after 50 mg threshold), but I'm troubled by some darkened moods lately just after starting it. It seems that I'm fine in the first half of the day but second half of the day my mood takes a plunge. I'm familiar that SSRIs can make people more depressed during the startup period of the drug, but I'm completely oblivious to whether atypical antipsychotics could have this effect aswell? So is it just a startup effect?
OR could this be a problem with dosing as I'm taking an instant release Seroquel before bed and the concentration changes too much through out the 24 h period I take the med? I just don't want to take it during the daytime as the drowsiness can be too much of a problem then.

Advice from experienced Seroquel users would be of great help! Thank you.




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