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Re: proof of superiority of branded/Zyprexa Phillipa

Posted by ed_uk2010 on April 30, 2010, at 13:36:26

In reply to Re: proof of superiority of branded/Zyprexa ed_uk2010, posted by Phillipa on April 28, 2010, at 21:25:53

> what is the difference between the active ingredient?

The active ingredient (the drug) is exactly the same, and is present in the same quantity.

For example, standard strength Prozac capsules contain 20mg of fluoxetine hydrochloride. The generic versions also contain 20mg of fluoxetine hydrochloride.

Generic products sometimes contain different excipients to the branded equivalent, but not always. 'Excipient' means anything other than the actual drug which is present in the tablet/capsule. Excipients are sometimes called 'fillers' but this is not particularly accurate because they serve numerous different functions.

For example........

Prozac 20mg capsules (UK version) contain the following excipients.......

1. Starch and dimeticone (powder inside the capsule, mixed with the fluoxetine powder)
2. Gelatin (the capsule shell)
3. Patent blue V, Yellow iron oxide and Titanium dioxide (colourings - used to colour the capsule with the familiar white and green shades)
4. Edible printing ink (used for the black writing on the outside of the capsule)

Compare this with generic fluoxetine capsules made by Winthrop UK........

1. Starch and dimeticone (the same as Prozac)
2. Gelatin (the same as Prozac)
3. Patent blue V, Erythrosine and Titanium Dioxide (colourings - slightly different to Prozac.....which is why the Winthrop generic capsules are blue and white rather than green and white)
4. Edible printing ink (as per Prozac)

In this case, the main difference between the brand and the generic is the colourings. Other differences may be present with different products.

Hope this helps.




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