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Re: Stimulants for TRD southernsky

Posted by SLS on November 14, 2009, at 6:27:12

In reply to Re: Stimulants for TRD, posted by southernsky on November 14, 2009, at 1:06:24

> It doesn't seem unreasonable to use drugs that enhance the dopamine system, imo. I'm not sure why it's more acceptable to target seratonin and noradreneline while ignoring dopamine...

I think the idea exists that anything that enhances dopaminergic neurotransmission through reuptake inhibition or synaptic release will produce addiction. Two very good antidepressants used in the 1980s were potent reuptake inhibitors of dopamine (DA). One of these, amineptine, displayed some addictive responses, but nothing to the degree of cocaine, another DA reuptake inhibitor. The other drug, nomifensine displayed no such addictive potential. There is also Wellbutrin, an antidepressant drug that is touted as being a DA reuptake inhibitor. So, things are not so simple as to be able to categorize all DA drugs as being addictive. Some of the new drugs in clinical stages of development are reuptake inhibitors of the three biogenic amines implicated in depression: serotonin (5-HT), norepinephrine (NE), and dopamine. Assigned the moniker "triple uptake inhibitors", I have not yet seen any indication that they display addictive properties.

> As for me-i don't see the delineation between personality disorders (character disorders) and neurotic depression/disorders,

What exactly is a neurotic depression?

- Scott




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