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Re: Stimulants for TRD

Posted by bulldog2 on November 13, 2009, at 16:43:09

In reply to Re: Stimulants for TRD bulldog2, posted by tensor on November 13, 2009, at 12:02:16

> > I've tried ritalin and adderall and they are good for the short term. Also the remission is not complete for montherapy. Just gets my head out of the water so to speak. The good part lasts several days and than goes down. If you keep chasing the euphoria the dose will escalate. For depression they probably need to be used as augmentation. Also need something to prevent tolerance as andrewb a former babbler found that memantine and adderall were his magic pills.
> > So I believe that stims have an important place in the p-docs tool box.
> > Before the advent of our new ads opiates and stims were the primary tools for depression. Have we found anything better in the last 50 years? At least opiates and stims didn't need three weeks to work. Now They don't work for everyone but I bet they would beat the 60% of the new ads.
>
> I agree, nothing really revolutionizing has happenened the last decades. Of course the newer meds have made the life easier but still.. On the other hand, older meds are tried and true, you know what you're up against, so to speak. Modafinil worked a long time, I wonder why it doesn't work anymore, anyway I will give my new combo some more time, then I will call my pdoc and ask for dexedrine.
> As you all know, it's frustrating watching the life pass by and have no energy, no impulses to do anything.
>
> /tensor

Yes I know what you mean. Most of the time I have the energy to get out of bed and force myself to do things. But also much of the time I derive no pleasure from life. I think this has gotten worse as I have gotten older. The color tv of my mind gets duller and duller. So I look for meds to get the color a bit brigter.

I remember as a young boy feeling happier after a teaspoon of codeine cough medicine. I didn't know what it was at the time so there was no placebo effect. So maybe I was born with a lack of pleasure endorphins. I always enjoyed my cough medicine when I was sick.

So maybe this was a vicious cycle. The cough medicine made me feel happy. But than after it wore off life seemed more dull. So I later pursued this happiness. But when off it I was even worse.

If you look at evolution and genetics there will be a variation in how many feel good endorphins one has. I've talked to people who say they get no effect from opiates. So are people who feel happier after a dose of opiates deficient in this substance?

If science could figure how how to conquer tolerance with stims and opiates you might have the best ads of the whole lot. The effect is immediate. Not perfect and not all respond to them. But I have a feeling the response rate might be better than the typical 60% of the other ads.

 

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poster:bulldog2 thread:925568
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