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Re: milk thistle - antidepressant?

Posted by Rosy Crucifiction on October 18, 2009, at 13:45:40

In reply to Re: milk thistle - antidepressant?, posted by Phillipa on October 18, 2009, at 12:05:53

Sloan Kettering has some good info:
"Clinical Summary

Derived from the seed, pod, or fruit of the plant. Silymarin, a flavolignan from milk thistle, is used primarily to manage various liver diseases. Placebo-controlled clinical studies show its efficacy in reducing aminotransferases in alcoholic liver disease (9) and conclusions from a systematic review also suggest usefulness of silymarin for liver cirrhosis (19). Studies for other types of hepatic disease are flawed (10) (11). Data from a randomized controlled study indicate benefits of milk thistle supplementation in improving glycemic profile in type II diabetic patients (18). In vitro and animal studies suggest that flavonoids in milk thistle have antioxidant and anticancer effects (7) (8) (12) (16) (17), but there are no clinical data on survival or quality of life.
One case of toxicity (sweating, nausea, vomiting, and weakness) has been reported from use of milk thistle (5). Milk thistle inhibits cytochrome p450 3A4 (4). This may result in increased levels of medications that are metabolized via this pathway."

When I drank heavily I took milk thistle extract daily. My liver enzymes where never a problem. Hallelujah, I needed all the enabling I could get.




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