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Re: Memantine as a reversible MAO Inhibitor?

Posted by Rosy Crucifiction on October 15, 2009, at 21:59:08

In reply to Re: Memantine as a reversible MAO Inhibitor?, posted by g_g_g_unit on October 15, 2009, at 17:43:03

I wondered the same thing. In addition (see below) because of memantine's long half life (60-80 hours) it may be that it just takes some people a long time to see MAO inhibition. I've emailed the folks at Merz about memantine as an MAO. I'll repost when I hear back. The authors had the following to say re: humans:

"Memantine is often administered to patients with Alzheimers disease; the doses administered are 20mg/d depending on the case.49)It is known that the plasma concentration of memantine reaches over 150ng/ml as Cmax following the administration of 20mg memantine to patients.50) This means that the plasma concentration of memantine might be above 0.7mM. Although memantine rapidly crosses the bloodbrain barrier,51) it is thought that this concentration might be too low to inhibit MAO activity.However, it is known that other monoamines such as 5-HT, DA and noradrenaline can be actively taken up into synaptosomes by the monoamine transporter where they are concentrated about 200-fold. In support of this report, we hypothesize that, in the brain, memantine may be concentrated in a similar manner and thereby reach effective concentrations. Thus, it is plausible that peripheral administration of memantine may inhibit MAO activity in the human brain, as well as having effects through NMDA receptor antagonism."




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