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Re: Effects of long term SSRI use... My Story...

Posted by metric on April 24, 2009, at 17:44:13

In reply to Re: Effects of long term SSRI use... My Story..., posted by SLS on April 20, 2009, at 7:19:11

> > >Unfortunately, Major Depressive Disorder and >Bipolar Disorder ARE progressive diseases in >that symptoms worsen over time.
> >
> > That is simply not true as a general statement.
> It took me 5 seconds on Medline to come up with this. There are quite a few more. Why do you even bother anymore?

I'm sorry, but it's not clear how this abstract is supposed to refute Linkadge's statement.

> - Scott
> 1: Int J Clin Pract. 2007 Dec;61(12):2030-40. Epub 2007 Oct 17.Click here to read Click here to read Links
> Neurobiology of depression: an integrated view of key findings.
> Maletic V, Robinson M, Oakes T, Iyengar S, Ball SG, Russell J.
> School of Medicine, University of South Carolina, Greer, SC 29650, USA.
> AIMS: The objectives of the present review were to summarise the key findings from the clinical literature regarding the neurobiology of major depressive disorder (MDD) and their implications for maximising treatment outcomes. Several neuroanatomical structures in the prefrontal and limbic areas of the brain are involved in affective regulation. In patients with MDD, alterations in the dynamic patterns of activity among these structures have profound implications for the pathogenesis of this illness. DISCUSSION: The present work reviews the evidence for the progressive nature of MDD along with associated changes in neuroanatomical structure and function, especially for the hippocampus. The role of glucocorticoids, inflammatory cytokines and brain-derived growth factors are discussed as mediators of these pathological alterations. From this integrated model, the role of antidepressant therapy in restoring normative processes is examined along with additional treatment guidelines. CONCLUSION: Major depressive disorder is an illness with significant neurobiological consequences involving structural, functional and molecular alterations in several areas of the brain. Antidepressant pharmacotherapy is associated with restoration of the underlying physiology. Clinicians are advised to intervene with MDD using an early, comprehensive treatment approach that has remission as the goal.
> PMID: 17944926 [PubMed - indexed for MEDLINE]




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