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Re: SSRI Induced HPTA Disruption

Posted by linkadge on February 7, 2009, at 13:23:35

In reply to Re: SSRI Induced HPTA Disruption linkadge, posted by SLS on February 7, 2009, at 8:28:35

Yes one is a middle aged man on sertraline and mirapex and the other is younger lady on paroxetine CR and mirapex. The man was originally on TCA's but had to change because of a cardiac issue.

In both cases, the SSRI alone was not controlling depression. Both the man and women stopped the SSRI because the mirapex produced such a rapid improvement. After relapsing, the SSRI was reinitiated and both are (apparently) doing well. They have been doing well for over a year.

The psychiatrist in my hometown is into using DA agonists for augmentation.

One study showed that the SSRI fluoextine can prevent tollerance to morphine. I am wondering if the SSRI's can act as anti-tollerance agents towards dopaminergics.

Linkadge


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poster:linkadge thread:878296
URL: http://www.dr-bob.org/babble/20090203/msgs/878737.html