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Re: How to decrease NE ? mav27

Posted by SLS on January 5, 2009, at 6:41:53

In reply to Re: How to decrease NE ? SLS, posted by mav27 on January 4, 2009, at 23:14:17

> I did look into desiprimine once but unfortunatly it turns out not to be available here in Australia :(
> I actually thought imipramine was working ok but the doc wasn't happy with it giving m a 120bpm heart rate

That is the nature of the beast. Elevated HR is an almost guaranteed side effect. If your doctor has a problem with it while you take the only drug that works for you, I would search for a new doctor or suggest to this one that he add the beta-blocker, propranolol. An added benefit to this drug is that it "calms down" NE throughout the brain as well as peripherally. There is some recent investigation into the use of propranolol in ADD. It is also used to help reduce explosive behavior.

Imipramine is the parent drug of desipramine. 20-30 years ago, it was used to treat adult ADD. It was effective enough to warrant its continued use. Desipramine is chosen more frequently now because of its reduced antcholinergic side effects. Desipramine is sort of a poor man's Straterra. It works, but has been largely forgotten about.

> plus i had NE induced sexual dysfunction... for me NE SD is different from seratonin induced dysfunction in that things work but it feels like someone has stuck a skewer through my prostate at -that- time.

I am familiar with this side effect. You are right about orgasm being driven by NE pathways. However, it might be the anticholinergic properties of imipramine that acts synergistically to produce this side effect. It tends to go away with time.

How long were you on imipramine for? This drug is also used sometimes to treat agoraphobia.

- Scott




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