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Re: I want to switch from nortriptyline to desipramine JadeKelly

Posted by SLS on January 3, 2009, at 20:00:09

In reply to Re: I want to switch from nortriptyline to desipramine SLS, posted by JadeKelly on January 3, 2009, at 19:28:58

> > I want to switch from nortriptyline to desipramine.

> I want a million dollars.

It's 2009. You'll need a lot more than that.

> Since both are tca's why a problem?

It is crucial not to choose a TCA that has significant serotonin reuptake inhibition properties. Even imipramine can produce serotonin syndrome when combined with MAOIs. Of course, clomipramine (Anafranil) is absolutely contraindicated for this reason.

> I am 50 pounds overweight and my triglycerides are well over 300mg/dL. I am sure that these are side effects of nortriptyline. I am betting that desipramine will substitute effectively for nortriptyline, as I once attained an extended remission when desipramine was combined with Parnate. I would need 300mg.

> Even tho thats a little higher than normal, Doc's do go over if they can check your heart, correct? I would think the health gain from losing 50lbs would outweight the concerns you've mentioned.

I am a rapid metabolizer of tricyclics.

> Btw- I checked on the amount of Abilify they prescibed for my son, it was total 20mg day. He gained ALOT of weight. He lost almost all of it when he switched to Seroquel.


> I thought I saw recently that they found there is some A/D property to Seroquel. I'm sure you know about it.

More recently, it has been recognized that a metabolite of Seroquel, N-desalkylquetiapine, is a potent inhibitor of NE reuptake - just like desipramine. I have seen Seroquel produce a robust antidepressant response in a friend of mine who added it to Wellbutrin.

> > I am very anxious to make this change.

> Good luck with it!


- Scott




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