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Re: How to decrease NE ?

Posted by SLS on January 3, 2009, at 8:24:03

In reply to Re: How to decrease NE ? SLS, posted by mav27 on January 3, 2009, at 8:02:03

I think the bottom line is that you might be right about your need to reduce the activity of NE pathways that use NE alpha2A receptors as a negative feedback loop. That you experience social phobia helps to bolster your theory. NE alpha2A receptors are concentrated in the amygdala, the major fear center in the brain. Taken together, the ADHD thing and the social phobia thing would merit an investigation into using clonidine, or, preferably, guanfacine.

Some people experience a "paradoxical" anxiolytic effect from D-amphetamine (Dexedrine). It might be interesting for you to give it a try. Perhaps now would be a good time for you to take a psychometric exam to look for ADD / ADHD. If the exam shows positive for attention deficit disorder, you might have an easy time getting a doctor prescribe amphetamine. I wouldn't recommend methylphenidate (Ritalin) as a first choice of stimulant. I think it would have a greater potential to produce anxiety.


- Scott


> > Hi.
> >
> > I'm having a tough time locating the literature that would be sufficient to show your doctor.
> >
> > I'll keep looking.
> >
> > Was ADD or ADHD ever suspected with you?
> >
> > Do you suffer from fear, anxiety, or panic attacks?
> >
> > Keep in mind that clonidine is well known to be depressogenic. However, there may be things about your individual biology that produce paradoxical reactions to NE alpha2 drugs. Guanfacine is less depressogenic and less sedating than clonidine. Both drugs are now used to treat ADD and ADHD. They serve to "calm down" NE activity in the prefrontal cortex (PFC).
> >
> >
> > - Scott
>
> I suspect i have some form of Adult ADHD... and if i was a child in this day and age i would bet my life i would be diagnosed with it... the signs of it being there when i was a kid are clear and even readsing old school reports you could see it... thing is back in my day no one knew what adhd was... and it doesn't help with australia being 10years behind the US when it comes to psychiatry.
>
> I believe i still have it in some form.... but any attempt ive made for drugs to treat it i just havnt had luck getting my hands on... anything even remotly related to stimulants are the most restricted drug and they don't recognise adult ADHD here as existing.
>
> Heres a recent newspaper article about it
> http://www.thedaily.com.au/blogs/is-it-just-me/2007/sep/07/adults-adhd/
>
> A lot of it sounds like me and i was that hyper kid that couldnt concentrate in class and always in trouble bcause i couldnt focus or be still for 1 second.... the only difference is they have spent the last 10 years trying to settle me with things like anti-psychotics but nothing has worked. (im 28 now)
>
> Around the age of 16 the depression set in and at 20 was diagnosed with anxiety and social phobia.
> Another of those wierd things i guess... on one hand saying i crave attention... on the other hand being afraid of it because i suffer anxiety attacks being around people and of being judged.
>
> I kind of feel like there is some wierd link 1ith one being the key.. like a triangle with 3 points... on the points being ADD, depression, and social phobia. One of those points is the key to breaking the triangle but we can't figure it out... and the only one we havn't... and can't work on well is ADD.
>
> There is 1 thing i know though... i've been on all the AD's in aus without luck.... the one thing that does temprerily fix my depression though is attention... it gets worse and worse and then i sms everyone on the phone that im going to kill myself.. post it on facebook, myspace ect... the more attention i get the better i feel and i live to suffer another day.

 

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