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Re: How to decrease NE ?

Posted by SLS on January 2, 2009, at 19:15:17

In reply to Re: How to decrease NE ? mav27, posted by bleauberry on January 2, 2009, at 16:57:50

> High dose VitC and magnesium will calm NE way down.

Any idea on how vitamin-C works to calm NE down?

Magnesium ion works by blocking the N-type calcium channels at NE nerve terminals and thus inhibits NE release. Would there be a therapeutic effect to treat depression if there were NOT a Mg deficiency? Would megadose treatment with Mg produce a long-term therapeutic effect or is it acute only, with feedback loops producing a loss of effect? I haven't been around anyone who has actually tried megadose Mg2+ treatments for MDD or BD, so I can't attest to its effectiveness.

Calcium is my nemesis. I become significantly more depressed after a single megadose. Calcium and magnesium are in some ways at opposite ends of the same pole. I found magnesium to be somewhat calming after the first few doses, but basically inert thereafter.

Lithium is a calming agent of NE neurons when used chronically. Interestingly, it produces elevations in the level of circulating Mg2+ ion. Mg2+ is essential to "calm down" glutamatergic NMDA receptors. It also helps to "turn off" NE release. Chronic use of lithium downregulates NE-alpha1/2 and NE-beta1/2 receptors. These represent long-term changes.

Using megadoses of magnesium and vitamin-C would seem innocuous in the absence of a calcium channel blocker. I guess bowel tolerance will tell you when you are taking too much of either Mg or Vitamin-C.

- Scott




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