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Re: can methylphenidate be combined with SJW? linkadge

Posted by Larry Hoover on January 1, 2009, at 22:04:02

In reply to Re: can methylphenidate be combined with SJW? Larry Hoover, posted by linkadge on January 1, 2009, at 21:02:04

> There are several compounds in SJW which inhibit monoamine oxidase to varying degrees. Was the study you refer to considering the whole plant extract?

Yes, it was. I couldn't find the questionable study, but I found the one that dismissed the earlier work. No one has ever replicated what the first study claimed.

http://www.ncbi.nlm.nih.gov/pubmed/7857511

> Anyhow, I have only heard that Green Tea inhibits MAO-B. Do you know of any studies suggesting it inhibits MAO-A as well.

No, as far as I know, the effect is limited to MAO-B. And very mild.

> Green tea is intersting. There is a 5 fold dopamine boost with green tea. It inhibits MAO-B, COMT and DAT activities. In addition, theanine displays some NMDA antagonist activity. Caffeine also causes dopamine release.

I think the biggest impact arises through COMT inhibition, but I'm sure the combination is potentiated.

> Just DON'T combine green tea with methylphenidate. I'll never make that mistake twice.
>
> Linkadge

I don't use either, but I'll remember your warning.

Lar

 

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poster:Larry Hoover thread:871806
URL: http://www.dr-bob.org/babble/20081223/msgs/871852.html