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Re: can methylphenidate be combined with SJW? linkadge

Posted by Larry Hoover on January 1, 2009, at 16:11:42

In reply to can methylphenidate be combined with SJW?, posted by linkadge on January 1, 2009, at 13:57:08

> Is there any interaction between a low dose of SJW (3-600mg) and low dose methyphenidate (5-10mg)?
> Linkadge

I can't find any evidence for an interaction. Methylphenidate is not metabolized by the P450 cytochrome enzymes, so the SJW induction of 3A4 can't be of any relevance. I did find one paper, a lone case report of a possible reduction in efficacy of methylphenidate by SJW, but there was no abstract, so I can't tell what it said. The decrease in efficacy may have been due to subjective additive effects, rather than an interaction per se.

I would have no hesitation giving it a try.

Good luck, and take care.





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