Psycho-Babble Medication | about biological treatments | Framed
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Re: Alpha1 vs Alpha2 question

Posted by desolationrower on December 12, 2008, at 0:47:06

In reply to Alpha1 vs Alpha2 question, posted by ricker on December 11, 2008, at 19:15:22

> I noticed Remeron as a NE alpha2 antagonist and Trazodone as a NE alpha1 antagonist. I'm taking remeron for sleep but am finding it is causing increased agitation/frustration. Does anyone have an opinion as to trazadones likelihood of causing the same effect? I'm sure the NE is causing my agitation but I do not know the difference between the 2 NE actions of the two meds?

They work in quiet different ways...most alpha2s are inhibitors receptors which stop NE or other neurones from firing. And a few alpha2 postsynaptically, i only know of them in relationship to adhd: they help promote concentration. Alpha1s don't help with concentration they are afaik exclusivly postsynaptic and excitory. I haven't seen it written anywhere but i think the alpha1 blockade basically just causes sedation/calm in the brain. The mirt is a promiscous drug, its hard to know how its causing agitation, but needless to say mirt and traz are very different drugs...





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