Psycho-Babble Medication | about biological treatments | Framed
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Re: melatonin and 5-HT receptors; ADD, dysexecutive

Posted by linkadge on November 16, 2008, at 5:49:38

In reply to Re: melatonin and 5-HT receptors; ADD, dysexecutive, posted by JadeKelly on November 15, 2008, at 23:40:13

Melatonin doesn't have direct affinity for 5-ht2a or 5-ht1a, but it has been shown to interact with the 5-ht2a / 5-ht1a receptor system.

It does act as a functional 5-ht2a antagonist and it does work to sensitize the 5-ht1a receptor in hippocampal regions (at least in mice)

What bearing this would have in your case I don't know.

Just as a side note, you seem to be very obsessed with your lack of prefrontal cortex function, yet you speak very logically and (at least from these posts) are seeming to be almost overanalytical.

Are you sure there isn't a core disorder that isn't still being adressed? I mean, it seems that you have the capacity for organized thought, do you have the motivation to carry things out?

Lack of motivation may be more than low prefrontal cortex function. My personal problem with coming off SSRI's is reward deficiancy. I just can't feel anything pleasurable.

I don't think this is due to prefrontal cortex malfcuntion as much as it is lack of rewarding neurotransmitter function in certain limibc regions.





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