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Better Detail Diagrams of Folate/Methylation Cycle Larry Hoover

Posted by Ron Hill on September 30, 2008, at 6:01:27

In reply to Re: Deplin: Dosage too high? bulldog2, posted by Larry Hoover on September 28, 2008, at 13:38:17

Lar,

Long time no talk.

FWIW, here are some flow diagrams with better detail of the Folate Cycle and the associated Methylation Cycle:

See page 5;
http://www.metafolin.com/pdfs/Scientific_Review_13.12.pdf

See Figure 1;
http://jn.nutrition.org/cgi/content/full/136/10/2653

Figure 1 (above) enlarged;
http://jn.nutrition.org/content/vol136/issue10/images/large/2653fig1.jpeg

Better diagrams of Stahl's than those he has on the Deplin website. See Figure 2 and Figure 5;
http://www.cnsspectrums.com/aspx/articledetail.aspx?articleid=1267

As an aside, here is an article from 2006 entitled "New and Emerging Treatment Options for Neuropathic Pain". I doubt that there is much, if anything, in the article that you are not already aware of, but I thought I'd send it along anyway.

What caught my eye when I first read the article a year or so ago is the tx of diabetic peripheral neuropathy (DPN) using a combination of L-methylfolate, P-5-P, and B12. See paragraph 10, not counting the abstract. DPN has nothing to do with your neuropathic pain, but here's the link anyway:
http://www.ajmc.com/Article.cfm?Menu=1&ID=3156

-- Ron

dx: Bipolar II, with ultra rapid cycling (15 days for one complete cycle), and mild OCPD

300 mg/day Trileptal
200 mg/day Lamictal
250 mg/day Keppra
60 mg/day Nardil


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