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Buprenorphine experiences Peter S.

Posted by kingcolon on September 22, 2008, at 0:26:47

In reply to Re: Does anyone have the original buprenorphine st, posted by Peter S. on September 21, 2008, at 22:51:30

Hi Peter,
I split the dose in two or three times a day intervals. The studies on depression, as well as for pain, seem to use split doses even though for addiction maintenance, a single daily dose is generally used. I think the biologic half-life is very short in comparison to the pharmacologic half-life. I do notice some "slipping" of mood toward the end of the dosing interval (say 6-10 hrs). The antidepressant effects did not occur instantaneously with me (unlike what is reported by others)--it took about a week to max out. There were anxiolytic effects almost immediately however. The sense of well-being it gave as well as it's motivating and anti-anhedonic effects have been the best of any medication I've taken over 15 years.
If others want to comment on their Sub experiences or add info on it, we should change the thread title since the original study was already referenced by undopaminergic.


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