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Re: agomelatine and hunger/weight desolationrower

Posted by Marty on September 21, 2008, at 17:19:23

In reply to agomelatine and hunger/weight, posted by desolationrower on September 21, 2008, at 17:08:08

> 5ht2c also greatly improves slow-wave sleep.
---
Antagonism, yes, but it also is stimulating and so it should be less effective than Ramelteon regarding sleep.

> The one side effect i worry about is weight gain. antagonising 5ht2c is speculated to be part of the reason olanzapine and clozapine cause so much weight gain, mirtazapine make people eat constantly, and cyproheptadine is used to help people gain weight. There are other drugs which don't match this though.
---
I thought it was 5-HT2a antagonism and also Histaminergic properties that made those drug weight-inducing. If you're right than I too is concerned by that aspect...

/\/\arty


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URL: http://www.dr-bob.org/babble/20080915/msgs/853276.html