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Re: Deplin: Dosage too high?

Posted by bulldog2 on September 16, 2008, at 17:17:49

In reply to Deplin: Dosage too high?, posted by SLS on September 14, 2008, at 11:14:32

> Deplin.
> If any of the following have been issues with taking Deplin, your dosage may be too high:
> 1. Poop-out at any point occurring after a robust response.
> 2. A worsening of depression after 1-2 weeks.
> 3. Vivid dreams or nightmares.
> 4. Mild brain zaps.
> I have restarted Deplin at 1/2 a 7.5mg tablet (3.75 mg) after a washout period of 2 weeks. After 2 days, I am starting to feel better. I am reluctant to make any predictions at this point, but the decision to experiment with a lower dosage of Deplin seems logical.
> - Scott

We do no that part of the process of deplin is conversion of homocysteine to methione to sam-e. Perhaps the 7.5 milligram dose of l-methylfolate depletes the stores of homocysteine so rapidly that eventually there is not enough left to convert to neurotransmitters. Perhaps a full pill is a good loading dose for deplin but once you acheieve the desired response try a half a pill and eventually even a quarter.




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