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Re: METHADONE + GRAPEFRUIT JUICE (AND OTHERS) robbieboy74

Posted by kingcolon on September 5, 2008, at 14:10:59

In reply to METHADONE + GRAPEFRUIT JUICE (AND OTHERS), posted by robbieboy74 on August 15, 2008, at 11:33:53

>


Provigil is a weak inducer of CYP3A4. Since methadone is metabolized by CYP3A, Provigil should somewhat decrease methadone levels. I have read literature of Provigil being used with opioids to counter the side effects of sedation, and there seems to be no clinically important interaction. I use buprenorphine, which is also metabolized by CYP3A, as well as Provigil, and the two seem OK together for me.


So guys! Does anyone know if grapefruit juice INCREASES or DECREASES the effects of methadone?
>
> What about provigil?
>
> What happens if you take methadone WITH provigil?
>
> What about lamictal? Does that do anything?
>
> I am prescribed lamictal and provigil and recently started methadone for...pain. I really want to know if they interact with each other, and also how they interact when grapefruit is thrown into the picture.


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URL: http://www.dr-bob.org/babble/20080903/msgs/850509.html