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Re: Parnate Dosage - Studies Proving 60+ Effective

Posted by Tomatheus on August 21, 2008, at 21:49:05

In reply to Re: Parnate Dosage - Studies Proving 60+ Effective eric wagner, posted by Nadezda on August 21, 2008, at 21:25:38

> Pharmacopsychiatry. 1989 Jan;22(1):21-5.

Here's the abstract of that study, which found that four out of seven participants with treatment-refractory depression were completely responsive to Parnate in doses ranging from 90-130 mg/day.



Abstract below from

1: Pharmacopsychiatry. 1989 Jan;22(1):21-5.Links

High dose tranylcypromine therapy for refractory depression.

Amsterdam JD, Berwish NJ.

Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia.

A substantial number of depressed patients will experience a chronic, treatment-resistant affective disorder. Aggressive treatment of these patients with various drug combinations, unconventional antidepressants, or electroconvulsive therapy has met with only partial success. There remains a pressing need to identify more effective methods of utilizing "first-line" antidepressant agents to achieve a more rapid therapeutic action. To this end, we initiated a study using high doses of the MAO inhibitor tranylcypromine, at a range of 90 mg to 170 mg daily, in seven refractory depressed patients who had failed to respond to at least three prior treatments regimens. Four out of seven subjects (57%), who had failed to respond to a mean of 8 +/- 5 prior treatment, had a complete response, and one patient had a partial response to high dose tranylcypromine. The mean SD maximum tranylcypromine dose for the responders was 112 +/- 16 mg daily (range 90 mg to 130 mg). Response did not appear to be a function of severity of illness, duration of present episode, or the number of prior treatment failures. Overall, the side effect profile was favorable, and no "cheese reactions" were encountered. These observations are of clinical significance and suggest the need for further controlled studies using high doses of tranylcypromine.

PMID: 2710808 [PubMed - indexed for MEDLINE]




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