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Parnate Dosage - Studies Proving 60+ Effective?

Posted by eric wagner on August 21, 2008, at 15:06:26

Does anyone know of any medical reports stating doses of Parnate above 60 mgs. are/can be effective?

I saw my Psychiatrist yesterday & have been on Tranylcypromine for 54 days w/ no positive response

5 days at 10 mgs.
5 days at 20 mgs.
6 days at 30 mgs.
10 days at 40 mgs.
7 days at 50 mgs.
21 days at 60 mgs.

I had asked him if he thought it would possibly be beneficial to gradually increase dose to 80 mgs./day &/or augment w/ a stimulant or tricyclic (Nortriptyline)

I have read posts where people didn't respond until their dosage was higher than 60 mgs. &/or augmented

My Dr. said there are no studies which prove doses above 60 mgs. are more effective if there is no response at a lower dose

The same w/ augmenting w/ a stimulant or tricyclic (contraindicated)

I believe my Dr. is not too well informed in prescribing MAOI's & does not do it much

He told me as the dosage of a MAOI is increased, the side effects are increased logarithmically

I did have bad side effects for 2 1/2 weeks when I hit 60 mgs. - especially dizziness/lightheadedness to the point when I stood up/walked a short distance, if I did not kneel/sit down, I felt like I was going to faint

Along with anxiety, insomnia, headaches, nausea, a hissing sound in my head which lasted about 20 seconds a couple times a day, lethargy, etc.

The side effects have since totally disappeared

I previously trialed Emsam for 12 weeks also w/ no response

He has previously stated we are running out of options

I just want to feel better & be able to live a worthwhile life

I have a high tolerance for medications - of the approximately 30 medications I have trialed over the past 10 years, I only briefly responded positively to Daytrana until tolerance set in after 2 weeks the 5 times & restarted it

I am a 33 year old active healthy male suffering for a long time w/ depression/ADHD

Any help/info. on the above (including where I may find the requested studies) will be very much appreciated

Take Care & Be Well,
Eric M. Wagner




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