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Re: does selegiline really mitigate DAergic cell l undopaminergic

Posted by SLS on June 20, 2008, at 13:17:09

In reply to Re: does selegiline really mitigate DAergic cell l, posted by undopaminergic on June 20, 2008, at 12:19:17

> Thanks for your display of appreciation, but you are exaggerating its magnificence.

Sorry UD. I guess I am too easily impressed. :-)

For some reason, the investigators at the NIH got spooked when two of their patients died of cardiovascular events. I think its effectiveness is due to both its irreversibility and its selectivity for the MAO-A enzyme. I have read that MAO-A is responsible for breaking down dopamine and norepinephrine in some areas of the brain. However, perhaps more important, is that clorgyline inhibits the reuptake of dopamine in various areas.

The usual dosage of clorgyline lies between 8 and 10mg. I went up to 15mg. They justified this high-dosage treatment by telling me that I was "very sick", and that they wanted to use their "ace-in-the-hole" compound, as it had demonstrated unusually high efficacy in their experiences. I was almost treatment-REFRACTORY at that time. Nothing budged my depression. Nardil and Parnate combined with TCA no longer worked. The ONLY drug that broke through the wall of resistance during this period of time was clorgyline. I remained partially responsive to clorgyline for quite a few months. However, when I asked William Potter if we could add desipramine, he refused. My doctor at home would not take responsibility for administering polypharmacy with clorgyline, so I decided to discontinue it in order to move on to other things.

I am relating to you what the investigative staff at the department of clinical pharmacology, NIMH, NIH told me. They thought it was more potent as an antidepressant than Nardil or Parnate.

Clorgyline and selegiline both have some interesting neuroprotective properties. Perhaps it lies in their propargyl structure that these two drugs exert these properties.

- Scott




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