Psycho-Babble Medication | about biological treatments | Framed
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does selegiline really mitigate DAergic cell loss?

Posted by iforgotmypassword on June 13, 2008, at 5:08:48

does it really stop natural dopaminergic brain cell loss over time (13% each decade of adult life?), or mitigate it to any degree?

this seems to be possibly implied on BLTC's neat selegiline page, and it seems to be a commonly held belief. is there documented basis, or hard research? was this effect on dopaminergic brain cells noted in the mice that selegiline was observed to extend the lives of? anything else?

there is a LOT on the selegiline page, but i have a lot of trouble reading properly, i am still in the process of that. so i am asking other people, just in case, for both new information and possible clarification of the impressions that i have already accumulated.

this is very interesting to me as my problems seem tied to buggered DAergic projections from the VTA. i am guessing it is more tied to it's mesocortical projections into the PFC. but it's projections into the NAc also seem relevant, as i have a hunch that dopaminergic effect in that NAc that lamotrigine has (thanks for sharing this, was it SLS? thank you whoever did?) that may be what makes it helpful to me, as i have restarted it. i am staying at 100mg, and i feel quite a bit more woken up. less stiff and akathitic, and my thinking is more dislodged, executive function notably better, but of course as usual far from ideal. but an improvement i am quite thankful for. it seems important that i take lorazepam to allow it to help me periodically.

anyway, the idea of keeping away the 13% (or what specific percentage) on average of DAergic cell loss each decade of adult life. does anyone have more on this? solid support of the idea that it does this?

(this issue, in this last paragraph above, is the main question(s) focused on it my post.)

thanks. as usual sorry for any incoherence. i think i did well this morning actually tho! at least in comparison to my usual, i think my fluency level goes along with DAergic function, thanks lamotrigine.




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