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Re: Suboxone???? Is it only for Opiates or an Ad Too?

Posted by rgb on May 28, 2008, at 17:16:08

In reply to Re: Suboxone???? Is it only for Opiates or an Ad Too?, posted by undopaminergic on May 28, 2008, at 2:32:05

Hello undopaminergic,

from what I've read so far, you remind me of myself a lot (intense psychopharmacology research, your self-observation after trying something new etc).

The thing with mu agonism is that it tends to solve just about any problem (with the possible exception of itching and nodding). It's all too easy to tell oneself that some specific therapeutic effect is happening... Your observations are easily explained by mild euphoria and the resulting effect of "Wow, it's doing something! Now I can do all these things I'd been too depressed to do!".

Just food for thought; I'm not to judge what is right for you. Neither am I saying that there is no such thing as endogenous opioid deficiency, just that a profound feeling of safety and protection happens to be pretty nice when the rest of one's life isn't so solacing :)

Not that there's anything wrong with euphoria; the question is what you'll do if it turns out that it doesn't last after you're already neurophysiologically and/or psychologically dependent on it. Incidentally, the prospect of this is what prevented me from trying long-term tramadol (or other low-potency opioids), which used to make a night-day difference for me on days of sporadic use.

Yes, the kappa antagonism thing is intriguing and makes bupe somewhat special, but IMHO you shouldn't let this distract you from the above mu agonism thing (partial or not, to my knowledge it's plenty for the non-tolerant user).

Best of luck,




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