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Re: Nardil Nightmare - very very long

Posted by undopaminergic on May 24, 2008, at 15:09:41

In reply to Re: Nardil Nightmare - very very long undopaminergic, posted by SLS on May 21, 2008, at 8:06:10

> > Also, hypotension can be treated, with fludrocortisone or stimulants.
>
> Which stimulants are better for this purpose? I was under the impression that Ritalin was the most effective.
>

I would expect that anything with a noradrenaline reuptake inhibiting action would have the most stabilising effect. An extended release forumulation of methylphenidate would be a good choice unless its dopaminergic properties cause side effects, in which case atomoxetine or reboxetine may be better choices.

Some theories about MAOI hypotension propose that it results from false neurotransmission by endogenous (and dietary) trace amines that are normally deactivated by MAO; these amines may displace noradrenaline from neuronal storage vesicles, and be released in place of the real neurotransmitter; to the extent that they lack adrenergic agonist activity, they would interfer with the normal activity of NA in regulating blood-pressure. Reuptake inhibitors would reduce the uptake of these amines into neurons and perhaps promote a healthy storage and release of noradrenaline.


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poster:undopaminergic thread:830220
URL: http://www.dr-bob.org/babble/20080519/msgs/830906.html