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Re: Zyprexa Sigismund

Posted by yxibow on December 1, 2007, at 2:51:23

In reply to Zyprexa, posted by Sigismund on December 1, 2007, at 0:23:02

> What's it feel like?
>
> (The only APs I've tried are the old ones, so I guess I am imagining some (horrible!) version of that.)
>
> But maybe it is completely different?

The two relatively EPS free atypicals, Zyprexa, and Seroquel once stabilized feel really quite different. No wanting to run through the walls with akathisia. Weight gain possibilities when not monitoring food and/or genetic susceptibility to Type-II Diabetes, yes.

Seroquel is somewhat more groggy than Zyprexa to me but all of these variables are quite different to the patient, and the dose taken which both have very wide ranges. They both tend to be their own antihistamines.

Orthostatic hypotension is a possibility because of the manner in which the drug touches certain receptors, so dont jump up suddenly until you're used to it. Lastly, fatigue also varies wildly and is dosal related and connected to the orthostatic hypotension to some degree. EPS is rather rare.

The chance of TD is always there, after 55 years we still have that, aggregate statistics would say 5% per year vs. 25% for the typicals but in general Zyprexa and Seroquel have very low rates and no large amounts of single-drug users have yet to date been shown. The BJP journal places a possibility of 0.5% per year on a mass study of Zyprexa but again, statistics are only a guidance and they aren't the end all to describe things.

Basically there's always a risk benefit, still. Maybe in 20 or 30 years someone will come out with something truly novel that still uses D2 and isn't Clozaril (which I'm prepared to take for personal reasons.)

A single dose of either is basically a sleeping pill. One has to adjust to them over a period of time.

 

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