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Re: Trivastal is an a2-adrenoreceptor antagonist?

Posted by linkadge on November 28, 2007, at 19:13:30

In reply to Re: Trivastal is an a2-adrenoreceptor antagonist?, posted by clipper40 on November 28, 2007, at 19:08:43

the a2 receptors are inhibitory autoreceptors.
They are invovled in homeostatic control over norepinephrine release. When you block these receptors it results in a *release* of norepinephrine. When you activate these receptors (like clonidine an alpha-2 agonist) you get less norepinephrine release.

So drugs like mirtazapine, trivestal, or yohimbine, alpha-2 antagonists, will cause norepinephrine release.





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