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Re: Getting Doctors to prescribe opiates FredPotter

Posted by Quintal on August 15, 2007, at 1:09:49

In reply to Re: Getting Doctors to prescribe opiates Quintal, posted by FredPotter on August 14, 2007, at 23:09:26

The Paramol + Nurofen Plus combo contains the equivalent of ~50mg codeine in total. Because codeine needs to be metabolized in vivo there's a ceiling effect to the amount that can be processed as a single dose, and 60mg is usually given as that amount. So we're getting pretty close to that using my combo, and if you can metabolize codeine properly (some people lack the enzyme) then you should feel some effect at that dose. If you can't, then you may be deficient in the liver enzyme CYP2D6, which according to Wiki, is the one that does all the donkey work in converting codeine into morphine.





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