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Re: SSRI's effect on norepinephrine ??? Jay_Bravest_Face

Posted by King of Nothing on August 9, 2007, at 17:02:24

In reply to Re: SSRI's effect on norepinephrine ??? Glydin, posted by Jay_Bravest_Face on August 9, 2007, at 16:43:00

> > I thought SSRI's, as a drug class, were very weak reuptake inhibitor of norepinephrine to the point of very little impact on norepi unlike SNRI's.....
> >
> > Can someone clarify this for me?
> If I recall correctly, Paxil is supposedly the most potent NRI that is classified as an SRI out of the drugs available in N. America. There has been some really huge arguments over the past few years about it even labeling Paxil, Prozac, Zoloft et al, as just "SSRI's". Some of their strongest characteristics may be the influence on Serotonin, but they certainly have been shown to affect numerous/and/or most .at least some of the other neurotransmitters. It all really came down to marketing. The drug companies wanted to present a "clean" a.d. that addressed their (ill thought-up) idea that Serotonin is/was the only major player in depression.(This is particularly true going back to the original launch of Prozac here in N. America. Prozac also effects both some dopamine and norepinephrine. EVERYTHING was linked to Serotonin) It is just they all have different "ratios" of how much the drug affects a particular neurotransmitter. Yes, some affect Serotonin more then others, but "SSRI" may be misleading.
> Jay :)

Great information Jay, Thank you.




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