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Re: beta carbolines to reverse benzo cognitive pro FredPotter

Posted by Quintal on August 8, 2007, at 20:22:58

In reply to Re: beta carbolines to reverse benzo cognitive pro Quintal, posted by FredPotter on August 8, 2007, at 19:02:10

Well here is the abstract of the study. All of your assumptions (and the conclusions you derived from them) seem to have been wrong Fred; note "Initial psychiatric examinations showed low symptom levels in all groups but no statistically significant differences among them." And: "but our data suggest that abuse of particular drugs has a major role in the development of specific psychiatric illnesses." Meaning that the benzodiazepines actually caused depression in previously healthy persons. The opiates did not.
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1: N Engl J Med. 1979 Dec 13;301(24):1310-4.Links
Development of psychiatric illness in drug abusers. Possible role of drug preference.
Mc Lellan AT, Woody GE, O'Brien CP.

The origin of the psychiatric illnesses observed in drug abusers is often unclear. This study examines the causal relation between drug abuse and specific psychiatric disorders. Fifty-one male veterans first seen in 1972, who were admitted at least once per year for six consecutive years for inpatient drug-abuse treatment, underwent psychiatric assessments at each admission. Eleven men mainly used stimulants, 14 depressants, and 26 opiates. Initial psychiatric examinations showed low symptom levels in all groups but no statistically significant differences among them. By the end of six years, five of the stimulant users had psychoses, and eight of the depressant users had serious depression. The narcotics users showed no change in psychopathology. Differences between the groups were significant at the 0.01 level. These changes were not due to acute toxic reactions, but our data suggest that abuse of particular drugs has a major role in the development of specific psychiatric illnesses. The possibility that different preexisting personality disorders lead to different kinds of drug abuse cannot be excluded.

PMID: 41182 [PubMed - indexed for MEDLINE]
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>6,3'-dinitroflavone has a partial agonist profile.

Yes Fred I know.

>which doesn't sound too promising.

On the contrary. That's probably why it lacks the amnesiant and cognitive blunting effects of the classical full agonists

>And only on rats so far

As with all research chemicals (including benzodiazepines) at that stage of testing. I'm not sure if these flavonoids can actually be patented, probably not. If so we never never see it tested on humans.

Q


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poster:Quintal thread:774284
URL: http://www.dr-bob.org/babble/20070808/msgs/774924.html