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Re: tianepyine + ssri/snri falconman

Posted by psychobot5000 on April 6, 2007, at 20:59:04

In reply to Re: tianepyine + ssri/snri, posted by falconman on April 4, 2007, at 16:18:53

> Hi,
> yeah but in terms of sertonergic activity only , do you think they would?
> > Tianeptine + remeron would probably not cancel, since remeron has noradrenergic activity as well.
> >
> > Linkadge

They shouldn't cancel each other's serotonergic activity, no.

Tianeptine works via encouraging reuptake inhibition, but Remeron acts specifically at receptors, at clinical dosages. It does not have any net effect on extrasynaptic serotonin levels--it sticks to blockading 5ht 2a, 2c and 5ht3 receptors. So it's unlikely to block tianeptine's presumed mechanism of action.

Tianeptine, in turn, does not have any (known) effects on serotonin receptors, so it probably wouldn't interfere with Remeron's receptor antagonism.

It's hard to say how they'd interact in practice. It seems, theoretically, like a sensible thing to try, though, and safe.




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