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Re: What is safe to augment with Nardil? football

Posted by iforgotmypassword on April 2, 2007, at 3:46:19

In reply to What is safe to augment with Nardil?, posted by football on April 2, 2007, at 2:52:00

i augmented parnate with desipramine for a few days, and it was notably effective combatting avolition, amotivation and cognitive paralysis, but wasn't a cure-all for any of these for me, maybe for someone else, or if i had stayed on maybe my response would have been more complete. despite putting more executive and volitional drive into me, i still felt as emotionally foggy as usual. maybe a difference here also would have been felt had i stayed on it.

i didn't stay on it, as it my own idea and no doctor was supervising it and approving that as a presciption for me. (despite an inpatient doctor who said he has done it, and would try it with me, but i was not in the hospital long enough.) there may be risks doing it alone without supervision, maybe cardiovascular or manic, so i wouldn't just recommend trying it yourself without talking to a doctor that's open to more advanced psychopharmacology. TCA+MAOI used to be used much more often before SSRIs and all of that stuff, i think.

presumably if parnate can be combined with desipramine, nardil can too.

i have heard of nardil being combined with nortriptyline, as well, likely here (SLS?), and if anything, if that can be done safely, there would be less to worry about with desipramine, as it has zero serotonergic effect practically.

nortriptyline may be more effective in some cases as it adds in 5HT2a blocking without D2 antagonism, though it is more anticholinergic than desipramine (may possibly be an annoying issue for some people), less norandrenergic (may not be a downside, at certain doses it may be equivalent to desipramine low-dose), and may also be a weak-ish antihistamine if i remember correctly.

i find that the norepinephrine reuptake effect of desipramine just as effective at low dose 50-100mg than at high dose 150-300mg. if you were doing this, you may easily not need any more than 50 (a typical starting dose even, i think) or maybe you would do well at even 25mg. it may be possible that the lower the better with this as even desipramine is anticholinergic, desipramine was the first drug to give me a bit of urinary retention.

anyway, in the end desipramine may possibly be more safer than nortriptyline for MAOI augmentation, and this is worth noting. still, nortriptyline has been used safely with MAOIs before... they both are worth asking about.




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