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Mirapex and Retinal Pathology in the Rat linkadge

Posted by Quintal on April 1, 2007, at 19:57:57

In reply to Re: Pergolide recalled, posted by linkadge on April 1, 2007, at 19:18:05

I know, thinking about it though 25mg/kg is one helluva high dose compared to what I've been taking; 0.125mg/70kg. Is that 0.002mg/kg? So the albino rats were taking ~12500 times more mg/kg than me? I'm no good at statistics so there's probably a flaw in my reasoning somewhere, but anyway there seems to be quite a considerable margin of safety. And I'm not an albino and rarely go out in full sunlight anyway. Another study with slightly lower doses failed to find the same results, and one with pigmented rats failed to show the retinal pathology at all at the same dose.

Q


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