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Re: Lyrica left me feeling worse. linkadge

Posted by SLS on October 27, 2006, at 0:05:08

In reply to Re: Lyrica left me feeling worse., posted by linkadge on October 26, 2006, at 17:01:06

Hi Linkadge.

> SLS reacts well to NRI's (?).

Actually, I reacted adversely to reboxetine. It exacerbated my depression severely and made me suicidal. Also, I find imipramine and nortriptyline better for me than desipramine. It seems that a mixture of 5-HT and NE reuptake inhibition produces a better effect for me than a selective NE reuptake inhibition.

> Isn't there a intricate relationship between noradrenaline and glutamatergic function?

I don't know how that works other than to characterize NE as being generally excitatory upon GLU pathways.

> Some studies linked positive response to TCA's with a dramatically increased affinitity of zinc to hippocampal neurons. I found zinc to be a better antidepressant than magnesium.

What dosage of zinc did you find helpful?

> Both are NMDA antagonists, but magnesium decreases BDNF while zinc upregulates it. Zinc also increases BCL-2 like lithium. BCL-2 increase supposedly has antidepressant effect. Valproate also increases BCL-2, but not other mood stabilizers.

Thanks for this information.

- Scott




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