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Re: Dexamyl for the menopause........ Ame-Sans-Vie

Posted by ed_uk on October 25, 2006, at 12:55:39

In reply to Re: Dexamyl for the menopause........ ed_uk, posted by Ame-Sans-Vie on October 25, 2006, at 7:16:59

Hi M

>that is an awesome resource!!!

I like it too :) It's good for researching discontinued drugs and drugs which were developed but never marketed. It goes all the way back to the bromides eg.

You can use the 'alphabetical index' or do a search.

>But any ideas as to why an anticholinergic (benactyzine) could exert antidepressant effects?

Not sure. Some have hypothesised that the anticholinergic properties of the TCAs may contribute to their efficacy as ADs. Tofenacine (Elamol), an anticholinergic derived from orphenadrine, was formerly marketed as an AD in the UK. Not convinced it was effective though. Even if it was, it might not have been the anticholinergic properties which made it effective.

Take care





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