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mirapex was wierd for me linkadge

Posted by iforgotmypassword on September 25, 2006, at 16:00:18

In reply to Re: how strong is buspar's D2 antagonism? iforgotmypassword, posted by linkadge on September 25, 2006, at 15:34:49

caused somnolence and cognitive fuzziness. was not good for mood at all.

my doctor thought i was getting better. maybe it cut off my negative outward signs or something... (in that case, thats an eerily SSRI-like effect for me)

one thing to note about Mirapex (pramipexole) is while the D3 activity is interesting, it seems to have a doumented higher affinity for dopamine AUTORECEPTORS, speaking of the devil.

at high doses though maybe this would not matter. sure enough, in studies judging non-parkinsonian, non-geriatric, neuropsychiatric theraputic effects, HIGH DOSES SEEMED TO BE THE WAY TO GO.

my doctor was extremely conservative with the dosing and very slow with increases. i do not believe i even got past 1.5mg. maybe i didn't even get that far.

ropinirole or whatever its called may be interesting as well though... it seems to have D3 action and may even have less presynaptic selectivity.

i guess all this is YMMV though on so many levels.

your symptoms, your physiology, and finally your doctor's mindset. :(


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poster:iforgotmypassword thread:689052
URL: http://www.dr-bob.org/babble/20060919/msgs/689128.html