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Re: Back on the stuff (amisulpride)

Posted by yxibow on September 3, 2006, at 15:43:55

In reply to Back on the stuff (amisulpride), posted by flip-floppy on September 2, 2006, at 11:33:40

> After trying Abilify for some days, and giving it up because it produced too much anxiety, I'm back on amisulpride again. A low dosage of amisulpride really has an extraordinary ability to enable me to shrug off intrusive thoughts and "psychotic panic attacks" as I call it... I thought increasing dopamine was not advisable for psychotic persons, but, really, is cocaine, for example, bad for psychotic persons? I don't understand this stuff... Anyway, I plan to take amisulpride until I can get a script for Seroquel.

Amisulpride or Seroquel are atypical neuroleptics, they reduce dopamine, not increase it, majorly at a specific transmitter D2 (dopamine sub 2) but also others as well, D1-4 (I beleive), depending on the antipsychotic involved. Amisulpride does agonize (increase) though certain receptors at a low dose and antagonize at a higher dose. Seroquel to the best of my knowledge does not, I use it, although not for psychosis.

Was the "anxiety" on Abilify something you could describe as unnatural to anxiety you've experienced, like you wanted to pace or walk through walls? If so, that's akathisia, an EPS, or side effect of neuroleptics. Seroquel, lowest on the list besides Clozaril, does not typically show this.




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