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Re: To Those Who Switched From Celexa to Lexapro.. bassman

Posted by SLS on July 13, 2006, at 15:06:12

In reply to Re: To Those Who Switched From Celexa to Lexapro.., posted by bassman on July 13, 2006, at 14:22:02

> Hey, Scott, I respect your opinion and I've seen a couple of the articles you cite. I just don't buy it and could produce a whole set of opinions that the ratio is 2:1 (and did in the first generation of this post). The only thing that bothers me with my prejudice is that I don't understand why some people get so anxious when they switch to Lexapro (?) As you know, AD's have difficulty in trials doing better than placebo, let alone the subtle is it 2 or 2+ for the Lexapro factor that we're talking about here. As I've said before, the experience that the average Celexa user uses 40 mg and the average Lexapro user uses 20 mg (more or less), is pretty convincing to me as well. I personally found the ratio to be 2:1 subjectively when I went from Celexa to Lexapro. But then, I could be 100% wrong!:>} Keep up your excellent posts, I always seek them out.
> bassman

The feeling is very mutual.

The thing is, I am beginning to see more and more people settling in on 60mg of Celexa. Numbers higher than that are being thrown around.

I guess this question is more esoteric than anything else, since each person must be titrated clinically anyway. I agree with you that 20mg of Lexapro is the way to go as the initial target dose.

Regarding the appearance of anxiety as a side effect of Lexapro, it is part of the personality of the drug, even when it is given as a de novo treatment. It usually appears about two weeks into treatment and disappears after the third. I am very intrigued that it should also appear upon crossover from Celexa. Sometimes all of the theorization we can muster cannot prepare ourselves for how these drugs act in real life. Perhaps it is the removal of the R- enantiomer antagonism of SERT inhibition that unmasks a pre-response anxiety (dig-dig). Actually, that explanation doesn't sound very plausible, but the observation is fascinating.

I should probably stop by Remedyfind every now and then. My lack of mental energy and focus usually preclude me from doing very much more than hanging out on Psycho-Babble for awhile and doing a few searches on Google or Medline. Nice life. :-(

- Scott




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