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Re: Interesting MAOI's infoChris

Posted by JaclinHyde on May 20, 2006, at 17:36:44

In reply to Re: Interesting MAOI's info JaclinHyde, posted by Caedmon on May 20, 2006, at 13:12:11

Here ya go Chris :-)

A great read all around!

Here is another interesting fact from it. I didn't know that the SSRI's also surpress REM sleep like the MAOI's do!

"MAOIs have prominent effects on sleep and sleep architecture, including a decrease in total sleep time and suppression of REM (rapid eye movement) sleep. The occurrence of REM sleep suppression has been associated temporally with an improvement in mood (39). In fact, REM suppression is a property shared by most effective antidepressants, including TCAs, lithium, and serotonin reuptake inhibitors. The extent to which the REM suppression caused by MAOIs contributes to the antidepressant effect itself remains unclear (42). Tentatively, both changes in sleep patterns and antidepressant responses have been linked to alterations in 5-HT regulation. Of the RIMAs, brofaromine has similar effects on sleep as the irreversible agents, whereas moclobemide does not have a striking REM sleep suppressant effect (42,109)."


> > "Both the irreversible MAOIs and the RIMAs rarely cause cardiac effects and at therapeutic doses have little effect on seizure threshold. Hepatotoxicity (e.g., progressive, necrotizing, hepatocellular damage) has occurred in some patients receiving MAOIs of the hydrazine type (e.g., phenelzine/Nardil) making it advisable to check liver function periodically in patients receiving high doses and in those receiving prolonged therapy with these drugs. Risk of hepatotoxicity with the non-hydrazine MAOIs (e.g., tranylcypromine/Parnate, pargyline, selegiline) and the RIMAs (e.g., moclobemide, brofaromine) is absent or minimal."
> >
> Interesting! BTW, do you happen to know the source? (It was a quotation after all.)
> - Chris




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