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Interesting MAOI's info

Posted by JaclinHyde on May 20, 2006, at 11:30:52

Here are two interesting facts concerning MAOI's

"However, it has been estimated that, of the 3.5 million patients that had used tranylcypromine (Parnate) by 1970, about 50 persons reportedly had cerebrovascular accidents and 15 of these individuals died (58)."

"Both the irreversible MAOIs and the RIMAs rarely cause cardiac effects and at therapeutic doses have little effect on seizure threshold. Hepatotoxicity (e.g., progressive, necrotizing, hepatocellular damage) has occurred in some patients receiving MAOIs of the hydrazine type (e.g., phenelzine/Nardil) making it advisable to check liver function periodically in patients receiving high doses and in those receiving prolonged therapy with these drugs. Risk of hepatotoxicity with the non-hydrazine MAOIs (e.g., tranylcypromine/Parnate, pargyline, selegiline) and the RIMAs (e.g., moclobemide, brofaromine) is absent or minimal."





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