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Re: interesting- re clonazepam and 5-HT transporte

Posted by SLS on April 21, 2006, at 16:05:46

In reply to Re: interesting- re clonazepam and 5-HT transporte, posted by linkadge on April 21, 2006, at 15:03:10

> I could be wrong, but I think that abstract is confusing since its refering to both presynaptic autoreceptors, and post synaptic 5-ht1a receptors in the forebrain as simply 5-ht1a receptors.

I am under the impression that 5-HT1a receptors in the hippocampus are primarily postsynaptic and inhibitory. Either way, it seems that these receptors are modulatory rather than excitatory.

I know this is simplistic, but it seems to me that pushing the system in one direction (SRI) or the other (tianeptine) results in the same thing. This would be a series of compensatory changes that produce a more functional balance of receptors and neurotransmitter.

- Scott




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