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Re: ENSAM Patch, parnate or nardil? Phillipa

Posted by Caedmon on April 21, 2006, at 8:40:15

In reply to Re: ENSAM Patch, parnate or nardil? Sobriquet Style, posted by Phillipa on April 20, 2006, at 19:55:10

Hi Phillipa, here is what I understand about the three, others are welcome to add their input:

EMSAM:
+ Easy, once daily application
+ Energizing, helpful for memory(?)
+ No diet restrictions
+ Motivating antidepressant
- Little research on anxiolytic properties
- Expensive
- New, so some adverse reactions may be underreported
- May cause agitation and insomnia
0 Usually causes slight weight loss
0 Still has the usual drug restrictions
0 Some amphetamine-like qualities
0 Brand-name ("Emsam") sounds much less dorky compared to the other MAOIs :p

PARNATE:
+ Very motivating, effective antidepressant
+ Some research as being good for social phobia, panic disorder
+ Easiest to augment?
+ Small doses = easier titration
+ Usually very fast-acting
- May cause agitation and insomnia
- Often requires multiple daily dosing
- Less forgiving of diet restrictions vs. Nardil
0 Usually weight neutral or causes weight loss
0 Some amphetamine-like qualities
0 Sedates some, activates others

NARDIL:
+ LOTS of research shows it helps anxiety
+ More forgiving of diet restrictions vs. Parnate
+ Bonus: good drug for those with high blood pressure
+ Metabolite increases GABA in parts of brain
- May cause major side effects: sexual, weight gain, hypotension
- Least forgiving of drug interactions (?)
- Takes a little longer to kick in vs. other MAOIs
0 Most people either love it or hate it
0 Usually not very activating

______________
Maybe that helps in making the decision? I tried to be impartial in my assessment. For me, Parnate had the profile that best matched what I needed so I'm trying that out. Best of luck,

- C


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