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Re: atenolol vs metoprolol

Posted by sdb on April 18, 2006, at 17:27:51

In reply to atenolol vs metoprolol, posted by mike99 on April 17, 2006, at 21:23:23

>metoprolol may be better on the whole for the >heart

These are a lot of questions.

Choosing a betablocker depends what you want to treat (...vs...)

You cannot generaly say one is the better than the other. Concerning sideeffects I would rate atenolol definately better. If you have a heart failure metoprolol, bisoprolol or carvedilol could be a treatment. But that should be monitored by a cardiologist (!). Metoprolol is more selective for beta1-receptors, both of them cause upregulation by time. Atenolol is longer acting but there is a sustained version of metoprolol you can take once a day. Important is to titrate those betablockers slowly up or if you want to stop titrate slowly down. There are some betablockers which do not cause upregulation. If you want to stop an adrenaline rush there are better options (measured mostly by isoprenaline).

It's very complicated. It depends what metabolizer you are and what variation in your beta1-receptor is.

In the β1 Adrenergic receptor gen are several polymorphisms

SR: Ser49Arg389
GR Gly49Arg389
SG: Ser49Gly389

~sdb


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