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Re: Anti-psychiatry has surpassed Goebbels SLS

Posted by Squiggles on April 7, 2006, at 8:39:11

In reply to Re: Anti-psychiatry has surpassed Goebbels Squiggles, posted by SLS on April 7, 2006, at 8:12:42

> > Well, i can't argue with that lol.
> >
> > But I wonder if there is any way to
> > separate observation of the effect of lithium directly on the thyroid (mania and anxiety being
> > naturally reduced by hypothyroidism) and
> > the 5-HT receptor activity - or are they
> > possibly correlated? Is it possible that
> > lithium is simply producing hypothyroidism
> > as an adjunct in depressives or drug-agitated
> > patients, as well a true manic-depressives?
>
>
> Hi Squiggles.
>
> The response to lithium can occur within a few days, so I doubt that the thyroid is involved. It takes awhile for the toxic effects of lithium to develop. The effects are dosage-dependent, so I wouldn't expect 300mg to produce thyroid toxicity, even in prolonged exposure.
>
>
> - Scott

OK - that's a good indirect argument;
a more convincing examination would be
to separate two groups given the same
lithium dose and see the results. I am not
sure what you mean by the "toxic" effects
as 600mg lithium is not toxic, unless
it interacts with another drug. Also,
the contention that it takes a long time
for the thryoid gland to respond is not
consistent with my experience. For example,
during a time of thyroid adjustment long
ago, i was overdosed with a thyroid dose
and within a week had manic-like effects,
inluding insomnia and appetite voracity.
While it is true that my dr. told me it would
take about 6 months to stabilize the thyroid
activity on a higher dose, certainly the effects
were immediate and very disturbing.

Squiggles


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